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liver disease

How supermolecule protects against liver disease

IMAGE: Microscopic pictures of liver biopsies of 3 people with totally different degrees of liver fat accumulation read more 

Credit: DIfE

The non-alcoholic fatty disease is that the most typical chronic liver disease within the world, with typically grave consequences. A high-protein, the calorie-reduced diet will cause harmful liver fat to soften away - a lot of effectively than a low-protein diet. a brand new study by Defi/DZD researchers revealed within the journal Liver bury national shows that molecular and physiological processes are doubtless concerned.

Causes and consequences of a non-alcoholic liver {disease}

Non-alcoholic fatty liver disease is characterized by a build-up of fat within the liver and is commonly related to fat, sort a pair of polygenic disease, high-pressure level, and macromolecule disorders. If left untreated, liver disease will result in liver disease with grave consequences. The causes of the illness vary from Associate in a Nursing unhealthy way - that's, consumption too several high-fat, high-sugar foods, and lack of exercise - to genetic parts. Already in previous studies, the analysis team LED by palladium Dr. Olga Ramich and academic Andreas Pfeiffer from the German Institute of Human Nutrition Potsdam-Rehbruecke (Defi) discovered a positive impact of a diet on liver fat content. "The new results now give us deeper insights into how the high-protein diet works," said Ramich, head of the analysis cluster Molecular biological process drugs at DIfE.

A diet is more practical than a low-protein diet

For this study, the analysis team LED by Ramich and Pfeiffer investigated however the supermolecule content of food influences the quantity of liver fat in weighty folks with non-alcoholic liver disease. For this, the nineteen participants were to follow either a diet with a high or low supermolecule content for 3 weeks. later, surgery to treat fat (bariatric surgery) was meted out and liver samples were collected.

Analysis of the samples showed that a calorie-reduced, diet attenuated liver fat a lot of effectively than a calorie-reduced, low-protein diet: whereas the liver-fat content within the high-protein cluster attenuated by around forty p.c, the quantity of fat within the liver samples of the low-protein cluster remained unchanged. The study participants in each team lost a complete of around 5 kilograms. "If the results continue to be confirmed in larger studies, the advice for Associate in Nursing magnified intake of supermolecule at the side of a healthy diet as a part of a good liver disease medical care might realize its approach into practice," said Andreas Pfeiffer, head of the analysis cluster Clinical Nutrition/DZD at Defi and also the Clinic for a medical specialty within the Charité -- Universitätsmedizin Berlin, field man of science.

Molecular fat absorption mechanisms

The researchers assume that the positive impact of the diet is especially thanks to the very fact that the uptake, storage, and synthesis of fat are suppressed. this can be indicated by intensive genetic analyses of the liver samples that academic Stephan Herzig and his team at Hermann von Helmholtz Zentrum München conducted. per these analyses, varied genes that are chargeable for the absorption, storage, and synthesis of fat within the liver were less active when the diet than after the low-protein diet.

Unexpected results

In addition, Olga Ramich's research group, at the side of the Department of Physiology of Energy Metabolism at DIfE, additionally investigated the functions of the mitochondria. "Mitochondrial activity was very similar in both groups. That shocked the North American nation. we have a tendency to originally assumed that the diet would increase mitochondrial activity and therefore contribute to the degradation of liver fat," said Department Head Professor Susanne Klaus. The researchers were additionally shocked that the liquid body substance levels of embryonic cell protein twenty one (FGF21) were lower when the diet that reduced liver fat than after the low-protein diet. "FGF21 is known to have beneficial effects on metabolic regulation. additional studies are going to be necessary to indicate why the issue was reduced within the truly completely acting diet," said Ramich. moreover, autophagy activity was lower in liver tissue when the diet compared to the low-protein diet. "Lipid degradation via 'lipophagy', as a special kind of autophagy, so doesn't seem to be concerned within the breakdown of liver fat in the diet."

As a next step, Ramich and Pfeiffer shall follow up their findings of the mechanisms concerned and therefore gain new insights into the mode of action of targeted dietary intervention ways.

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Publication

Xu, C., Markova, M., Seebeck, N., Loft, A., Hornemann, S., Gantert, T., Kabisch, S., Herz, K., Loske, J., Ost, M., Coleman, V., Klauschen, F., Rosenthal, A., Lange, V., Machann, J., Klaus, S., Grune, T., Herzig, S., Pivovarova-Ramich, O., Pfeiffer, A. F. H.: diet a lot of effectively reduces viscus fat than low-protein diet despite lower autophagy and FGF21 levels. Liver Inter. in press (E-pub prior print) (2020).

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